The study of the mechanism of action of different doses of atorvastatin on structural and functional condition of the great arteries in patients with acute myocardial infarction of the left ventricle

Research field: Medical chemistry, pharmacology

Project leader: Oleynikov V.E., DM, professor, Head of the department “Therapy”

Key words: acute myocardial infarction, atorvastatin, arterial rigidity, pulse wave, great arteries

Problem

There is a problem with the definition of the mechanisms of the effect of statins in high doses to improve the prognosis in acute myocardial infarction of left ventricle in post-MI period.

Importance

It is the actual to use the drugs, allowing to improve the course and prognosis of the disease in patients with acute myocardial infarction to reduce the high morbidity and mortality. Existing data on the application of high-dose statin therapy in this group of patients is only partially explained by the lipid-lowering effect of the drugs.

Research Originality

Scientific novelty lies in a comprehensive approach the study of the structural and functional condition of the arteries. The study includes an analysis of the characteristics of the pulse wave of the great arteries, the definition of elasticity and rigidity of the vascular wall, pulse wave velocity in different parts of the arterial bed.

Expected outcomes and their importance

High-dose statin therapy through the pleiotropic action leads directly to a decrease in severity of arterio- and atherosclerosis of vessels of various caliber, confirming the need for the use of lipid-lowering therapy in acute myocardial infarction of the left ventricle.

Sphere of application

Cardiology

Publications (WoS, Scopus)

1. Oleynikov V.E. Shigotarova E.A., Kulutsin A.V. Sergatskaya N.V. Silent myocardial ischemia in acute coronary disease // Therapeutic archive, 2015. – Issue 9. – P. 97-100.
2. Oleynikov V.E., Sergatskaya N.V., Gusakovskaya L.I., Khromova A.A. The state of the large arteries in patients with the type II diabetes mellitus suffering from the obstructive apnoea syndrome // Therapeutic archive. – M., 2015. – Issue 10. – P. 26-30.
3. Oleynikov V.E., Lukianova M.V., Dushina E.V. Sudden death predictors in patients after myocardial infarction by holter ECG monitoring // Russian Journal of Cardiology. – 2015. – Issue 3. – P. 108-116.
4. Oleinikov V., Sergatskaya N., Gusakovskaya L., Nagapetyan N. Markers of arterial stiffness according to daily monitoring and office measurement in patients with diabetes in combination with hypertension // European Journal of Preventive Cardiology. – 2015. – V. 22, issue 1 (suppl.). – P. S102.
5. Romanovskaya E., Tsibiskina O., Kishine M., Oleinikov V. Assessment of dependence of global deformation characteristics of myocardium in patients with STEMI from effective conduct of reperfusion therapy // European Journal of Preventive Cardiology. – 2015. – V. 22, issue 1 (suppl.). – P. S127.
6. Oleinikov V., Lukyanova M., Dushina E., Kulyutsin A. Heart rate variability in patients with arterial hypertension 1-2 degree and healthy subjects// European Journal of Preventive Cardiology. – 2015. – V. 22, issue 1 (suppl.). – P. S142.
7. Sergatskaya N.V., Gusakovskaya L.I., Dushina E.V., Oleynikov V.E. Structural and functional properties of arteries according to volume sphygmography in patients with diabetes mellitus and arterial hypertension // Journal of Hypertension. – 2015. – V. 33 (e-Suppl. 1). – P. e174.
8. Melnikova E.A., Gusakovskaya L.I., Tomashevskaya Y.A., Matrosova I.B. Comparative characteristics of local stiffness parameters in healthy subjects and patients with arterial hypertension of 1-2 degrees // Journal of Hypertension. – 2015. – V. 33 (e-suppl. 1). – P. e308.
9. Sergatskaya N.V., Gusakovskaya L.I., Nagapetyan N.T., Chromova A.A., Oleynikov V.E. Central pressure and vascular stiffness in patients with arterial hypertension and metabolic disorders according to daily monitoring // Journal of Hypertension. – 2015. – V. 33 (e-suppl. 1). – P. e317.
10. Oleynikov V.E., Eliseeva I.V., Borisova N.A., Fadeeva S.S., Gusakovskaya L.I. Compliance to therapy and blood pressure control in older patients with arterial hypertension of 1–2 degrees// Journal of Hypertension. – 2015. – V. 33 (e-suppl. 1). – P. e409.
11. Gusakovskaya L.I., Tomashevskaya Y.A., Khromova A.A., Oleynikov V.E. Parameters of central aortic pressure and renal function in patients with metabolic syndrome during the 16-week pharmacotherapy// Journal of Hypertension. – 2015. – V. 33 (e-suppl. 1). – P. e454.
12. Oleynikov V., Gusakovskaya L., Matrosova I., Sergatskaya N. Indicators of central pressure and rigidity during the long-term therapy of calcium antagonists in patients with metabolic syndrome and hypertension // Atherosclerosis. – 2014. – Vol. 235 (Issue 2). – P. e265.
13. Oleynikov V., Matrosova I., Melnikova E., Tomashevskaya J. Parameters of local vascular stiffness in healthy subjects and patients with coronary artery disease combined with hypertension 1-2 degrees // Atherosclerosis. – 2014. – Vol. 235 (Issue 2). – P. e232-e233.
14. Oleynikov V., Galimskaya V., Donchenko I., Romanovskaya E. The features of the myocardial deformation characteristics in patients with coronary artery disease, defined by the technology X-Strain // Atherosclerosis. – 2014. – Vol. 235 (Issue 2). – P. e230-e231.
15. Oleynikov V., Sergatskaya N., Gerasimova A., Fadeeva S. Influence of CPAP therapy on parameters of vascular stiffness in patients with type 2 diabetes // Journal of Hypertension. – 2014. – Vol. 32 (e-Suppl. 1). – P. e255.
16. Oleynikov V., Gusakovskaya L., Eliseeva I., Matrosova I. Influence of carvedilol therapy on central and peripheral pressure according daily monitoring blood pressure in patients with metabolic syndrome // Journal of Hypertension. – 2014. – Vol. 32 (e-Suppl. 1). – P. e372.
17. Oleynikov V., Eliseeva I., Gusakovskaya L., Fadeeva S., Borisova N. Dynamics of arterial stiffness parameters and compliance in patients older than 60 years to long-term antihypertensive therapy // Journal of Hypertension. – 2014. – Vol. 32 (e-Suppl. 1). – P. e372.
18. Oleynikov V., Gusakovskaya L., Borisova N., Tomashevskaya J. Factors affecting the daily parameters of central aortic pressure and rigity in normotensive subjects according to the ambulatory monitoring // Journal of Hypertension. – 2014. – Vol. 32 (e-Suppl. 1). – P. e606.
19. Oleynikov V., Lukyanova M., Kulyutsin A. Dependence the heart rate frequency characteristics of the age among the healthy individuals individuals according holter ECG monitoring // Journal of Hypertension. – 2014. – Vol. 32 (e-Suppl. 1). – P. e606.
20. Oleynikov V., Kulyutsin A., Shigotarova E. Assesment ot the ST dynamics by telemetry ECG method to determine the indications for emergency angioplasty after thrombosis // European Heart Journal. – 2014. – Vol. 35 (Abstract Suppl). – P. 461.
21. Oleynikov V., Sergatskaya N., Gusakovskaya L. Complex influence of metabolic syndrome and OSA on the vascular remodeling in patients with hypertension // European Journal of Preventive Cardiology. – 2014. – suppl. 1. – Р. 34.
22. Oleynikov V., Gusakovskaya L., Sergatskaya N., Tomashevskaya J. Daily values of central pressure and arterial stiffness in patients older than 60 years with systolic-diastolic, and isolated systolic hypertension // European Journal of Preventive Cardiology. – 2014. – suppl. 1. – Р. 105.
23. Oleynikov V.E., Matrosova I.B., Gusakovskaya L.I., Sergatskaya N.V. Role of the determination of aortic pressure and rigidity aortic in patients with cardiovascular diseases // Therapeutic archive. – 2014. – V.86 (4). – P. 91-95.
24. Matrosova I.B., Melnikova E.A., Oleynikov V.E. Effects of olmesartan on local and regional rigidity of arteries in ischemic heart disease// Cardiovascular Therapy and Prevention. – 2014. – V.13 (3). – P. 41-46.
25. Oleynikov V.E., Shigotarova E.A., Kulyutsin A.V., Evstigneev S.V. Improvement of rethrombosis diagnostics in steacs patients with use of telemonitoring of ECG // Russian Journal of Cardiology. – 2014. – Issue 9. – P.97-42.
26. Galimskaya V.A., Donchenko I.A., Romanovskaya E.M., Oleynikov V.E. The Features of Myocardial Deformation of Left Ventricle in Patients With Ischemic Heart Disease Defined by the Two Dimensional Strain Method // Cardiology. – 2014. – Issue 9. – P.11-16.
27. Oleynikov V.E., Matrosova I.B., Melnikova E.A. Corrective effect of olmesartan on parameters of the local rigidity using the echo-tracking technology // Cardiology. – 2014. – Issue 9 – P. 39-45.
28. Oleinikov V., Matrosova I., Galimskaya V., Melnikova E. Effect of statin therapy on structural and functional properties of arteries, lipid profile and C-reactive protein in patients with coronary heart disease // European Journal of Preventive Cardiology. – 2013. – № 20 (suppl. 1). – Р. 22.
29. Oleynikov V.E., Gusakovskaya L.I., Sergatskaya N.V., Matrosova I.B. Predictors of endothelial dysfunction and sleep-disordered breathing in patients with metabolic syndrome // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e271.
30. Oleynikov V.E., Gusakovskaya L.I., Eliseeva I.V., Fadeeva S.S. Dynamics of central pressure and arterial stiffness in elderly subjects with hypertensive background 24-week pharmacotherapy // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e322.
31. Oleynikov V.E., Tomashevskaya Y.A., Eliseeva I.V., Matrosova I.B., Melnikova E.A. Dynamics of central pressure and arterial stiffness in elderly subjects with hypertensive background 24-week pharmacotherapy // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e322.
32. Oleynikov V.E., Tomashevskaya Y.A., Eliseeva I.V., Matrosova I.B., Melnikova E.A. Indicators of insulin resistance and lipid metabolism in non-smokers and tobacco patients with metabolic syndrome // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e488.
33. Oleynikov V.E., Gusakovskaya L.I., Eliseeva I.V., Tomashevskaya Y.A., Borisova N.A. Features of the aorta structural and functional properties in elderly patients with isolated systolic hypertension according 24-hours monitoring // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e517.
34. Oleynikov V.E., Kulutsin A.V., Lukyanova M.V., Sergatskaya N.V. Frequency characteristics of heart rate in essential hypertension and metabolic syndrome // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e535.
35. Oleynikov V.E., Gusakovskaya L.I., Sergatskaya N.V. Factors determined the parameters of cardiorespiratory monitoring in patients with type 2 diabetes and hypertension // Journal of Hypertension. – 2013. – Vol. 31 (e-suppl. A). – Р. e271.
36. Oleinikov V.E., Galimskaya V.A., Donchenko I.A. Assessment of characteristics of myocardial deformation in healthy subjects of various age groups by the X-strain echocardiography // Cardiology. – 2012. – Issue 2. – P.65-69.

Дата создания: 28.11.2017 14:07
Дата обновления: 28.11.2017 14:15